Phytosterol ester substrate specificity of pancreatic cholesterol esterase
نویسندگان
چکیده
منابع مشابه
Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase.
Consumption of plant sterols or stanols (collectively referred to as phytosterols) and their esters results in decreased low-density lipoprotein cholesterol, which is associated with decreased atherosclerotic risk. The mechanisms by which phytosterols impart their effects, however, are incompletely characterized. The objective of the present study is to determine if pancreatic cholesterol ester...
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Cholesterol esters, which can comprise over 75% of total cholesterol in diets rich in organ meats, must first be hydrolyzed by pancreatic cholesterol esterase (EC 3.1.1.13) before being absorbed (1). In its hydrolytic mode, catalysis by the enzyme involves a classical serine esterase mechanism in which the seroxide anion displaces the sterol moiety to give an acyl-enzyme intermediate, followed ...
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It has long been known that enzymically catalysed synthesis and hydrolysis of cholesterol esters occurs in the presence of certain tissues (Kondo, 1910a, b; Schultz, 1912; Cytronberg, 1912; Gardner & Lander, 1913; Mueller, 1916a, b; Porter, 1916; Nomura, 1924a, b; Shope, 1928; Nedswedski, 1935, 1936; Klein, 1939; Sperry, 1935; Sperry & Stoyanoff, 1937, 1938). The most extensive recent studies, ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.722.15